Insights and Solutions: Research Initiatives

At RIZE, our commitment to combating the opioid overdose crisis drives our innovative approach to funding research. We prioritize generating and disseminating knowledge to enhance visibility, broaden the evidence base, and inform effective policymaking. Recognizing the evolving nature of the overdose crisis, we aim to learn and share our findings to benefit the entire field.

Our strategy focuses on investing in forward-thinking research that strengthens the evidence base and equips policymakers, addiction treatment providers, and our community partners with valuable insights. We support rigorously designed research methodologies—quantitative, qualitative, and mixed methods—that thoroughly test the impacts of programmatic or policy interventions on the opioid overdose crisis. This includes academic research, landscape analyses, white papers, and economic studies.

RIZE actively funds investigator-led research and commissions targeted projects that align with our areas of interest. We are resolute in our pursuit to understand what interventions work best, sharing our findings to drive meaningful change with urgency and determination. By identifying system-level considerations and advancing public policy, RIZE is committed to creating impactful, long-term solutions that benefit those affected by opioid use disorder and enhance the overall well-being of the Commonwealth of Massachusetts. Our efforts aim not only to improve individual lives but also to strengthen communities across the state, fostering a healthier future for all residents.

Grantees

Institute for Community Health: Evaluation of Mobile Methadone Programs (2024)

Principal Investigator: Ranjani Paradise, PhD, Director of Evaluation, Institute for Community Health

This project evaluates current and emerging mobile methadone programs in Massachusetts. Methadone treatment is an effective treatment for opioid use disorder; however, under federal regulations, methadone is only available through Opioid Treatment Programs (OTPs) and patients have to make regular visits to an OTP to receive their medication. This can present a significant barrier to access for some patients. The Bureau of Substance Addiction Services (BSAS) in Massachusetts has been investing in alternative models for methadone delivery, including mobile vans. There are five mobile methadone programs already established or in development in Massachusetts, yet there is limited research on mobile van methadone models and their patient outcomes. To enhance access to methadone, evaluating implementation and outcomes of varying service approaches is essential. This project is a two-year evaluation of the five mobile methadone programs in Massachusetts. RIZE is co-funding with BSAS.

Institute for Community Health: Inpatient Addiction Consult Services in Massachusetts - Insights and Recommendations from Six Model Programs (2022)

Principal Investigator: Ranjani Paradise, PhD, Director of Evaluation, Institute for Community Health

RIZE engaged the Institute for Community Health (ICH) to describe and document the state of hospital-based addiction care in Massachusetts. The project profiled a cross-section of diverse and existing care models, with associated best practices and challenges, and identified opportunities to improve care models and enhance harm reduction practices.

Working with RIZE, and expert advisors with direct knowledge of the local addiction care landscape, ICH refined the areas of inquiry and identified six hospital programs in Massachusetts to profile. Through interviews and document review, ICH described models at each of the hospitals and identified successful practices and challenges, including operational and financial considerations. ICH also conducted a literature review to document care models in other settings and summarized data from the Boston Overdose Linkage to Treatment Study to identify important elements of care from the perspectives of diverse community members at high risk for overdose. ICH synthesized all data and reported findings with recommendations to enhance harm reduction practices in hospital-based settings.

Read the report of these findings, published in February 2024.

Boston Medical Center Corporation: Understanding the Barriers and Facilitators to Harm Reduction in Shelter Settings (2022)

Principal Investigator: Avik Chatterjee, MD, MPH, Addiction Specialist, Boston Medical Center

Overdose is the leading cause of death among people experiencing homelessness. Harm reduction policies, including naloxone distribution and syringe exchange, can decrease the mortality and morbidity associated with high-risk substance use. Yet access to harm reduction practices tends to vary from shelter to shelter. The goals of this project were to better understand what practices are in place, why and how they are used, and generate an actionable set of next steps to enhance or implement harm reduction practices in shelter settings. The study also aimed to document how these practices impact shelter guests’ substance use and their use of shelter services and learn from people with lived and living experience to better understand the attitudes toward and knowledge of harm reduction in shelter settings. The study also collected ideas from shelter staff and guests about which harm reduction practices are the most supportive of their needs. The team hired consultants with lived and living experience to provide meaningful feedback on study design, recruitment plan, interview script, interpretation of findings, and how best to present findings in a manuscript and in communication back to shelters. The findings and recommendations were compiled into a toolkit in fall 2024. RIZE also hosted a webinar to present and discuss the findings in partnership with Boston Medical Center.

Boston Public Health Commission, Institute for Community Health, and Boston Medical Center: Boston Overdose Linkage to Treatment Study (2019)

Principal Investigators: Ranjani Paradise, PhD, Director of Evaluation and Research and Evaluation, Institute for Community Health & Dan Dooley, PhD, Director, Research and Evaluation Office, Boston Public Health Commission

The research project examined the experiences and service-seeking behaviors of diverse Boston residents in the 30 days following an opioid overdose in order to understand factors that influence access to treatment and identify opportunities for systems change. Guided by a research steering committee from three institutions – Boston Medical Center, Boston Public Health Commission, and Institute for Community Health – this project offered an in-depth qualitative review with input from the people directly affected, along with key stakeholders from local health care and public health programs. The combined perspectives allowed the research team to gain a deep understanding of barriers and identify actionable recommendations and inform policy and practice change for the health care and public health systems in Boston. The report is available here.

Brandeis University, Institute for Behavioral Health: Racial Disparities and the Role of Prescriber Networks in the Development and Sustaining of Buprenorphine Prescribing by Waivered Physicians for Opioid Use Disorder Treatment in Massachusetts Communities (2019)

Principal Investigator: Peter Kreiner, PhD, Senior Scientist, Institute for Behavioral Health

This project explored how isolated physician networks can negatively impact care coordination and information sharing among physicians. It identified system-level factors associated with the development and sustaining of buprenorphine prescribing in a community, structural properties of prescriber patient-sharing networks in which waivered physicians are embedded, and how these properties vary in relation to community demographics, including racial/ethnic makeup. Identifying network properties associated with greater access to opioid use disorder (OUD) treatment and with increases in treatment access outlines opportunities for system change efforts to reduce racial/ethnic disparities in access to OUD treatment.

The report is available here.

Tufts University, School of Dental Medicine: Controlled Substance Risk Mitigation in Dentistry: Testing a Validated Curriculum for Practicing Dentists, Dental Hygienists, and Oral Surgeons (2019)

Principal Investigators: Ronald Kulich, PhD, and David Keith, DMD, BDS

Until recently, dentists have been among the most frequent prescribers of short-acting opioids, with dentists prescribing more unused pills following dental procedures than prescribed by physicians after a wide range of medical/surgical interventions. Two-thirds of practicing dentists still believe that it is not within their professional role to screen patients for substance use disorders, a fact that is likely related to the slow adoption of prescription monitoring program utilization by general dentists. This project created a series of 10 validated controlled substance risk mitigation modules for Massachusetts practicing dentists, dental hygienists, and oral surgeons to promote safer controlled substance prescribing and to enhance appropriate screening, referral, and follow-up for high-risk individuals encountered in dental settings.